The aim of the research in this area is to characterise the genetic factors underlying brain ageing and its related disorders, in particular the different forms of dementia. This work is conducted in close conjunction with the clinical work routinely carried out at the Golgi Institute and is also linked to the Foundation’s neuropathological research.
It involves genotypic characterisation of patients, screening for known mutations and polymorphisms, screening of new candidate genes thought to influence (both positively and negatively) normal and pathological ageing, and analysis of certain biological parameters. Putting together the results of genetic and molecular studies and clinical data, it is possible to obtain, according to various parameters, specific profiles of individual patients. Furthermore, the planned investigations will be closely related to the Foundation’s experimental development of new models that, it is hoped, will finally open the way for truly effective care and treatment of these patients.