The InveCe.Ab (Brain Ageing in Abbiategrasso) Study
“InveCe.Ab” (Invecchiamento Cerebrale ad Abbiategrasso) is a longitudinal, population-based study of disorders of brain ageing involving the assessment and long-term monitoring of the physical conditions and cognitive status. The target population comprises all Abbiategrasso residents born between 1935 and 1939 – a reference sample, according to Population Register data, of around 1,700 people.
2010 - Baseline population assessment
This phase consisted of a complete socio-environmental, clinical and neuropsychological assessment of the population under study.It began in mid-November 2009 and ended in January 2011.
In this phase of the study two appointments per participant were scheduled at the Foundation (or at home if necessary). A total of 1,321 people agreed to take part (77% of the reference sample, 80.2% of the members of the reference sample who could actually be recruited).
2011- Allena-Mente Study
The Allena-Mente study is a randomised controlled trial comparing the efficacy of two group therapy approaches: cognitive stimulation sessions vs lifestyle education sessions. Around 180 people extracted from the study population were randomly allocated to the two treatment interventions. These lasted from February 2011 to the end of 2011.
2012 - First (intermediate) follow-up of the population
The first follow-up phase began on February 6, 2012 and consisted of a second multidimensional assessment of the individuals who had taken part in phase 1; any clinical events that had occurred since the first assessment were recorded. This phase also included an analysis of the incidence of dementia and mild cognitive impairment and an analysis of risk and protective factors. Phase 2 ended on February 28, 2013. A total of 1,113 people took part in this phase, corresponding to 84.25% of the baseline population and 90% of its members who could be recruited.
2013 - Assessment of the data collected and a study of family caregivers
For the purpose of conducting a study of family caregiver burden, a group of relatives of individuals participating in the study was selected. These relatives were interviewed by members of the Foundation’s team. This data collection phase lasted until the end of April 2013.
Molecular/genetic testing: blood samples collected from the participants were used for testing some new genetic factors and to analyse a series of biological parameters, comparing them with the data from the baseline and first follow-up assessments.
Data processing: The mass of data collected during the second assessment was processed but in particular the researchers began to see what could be deduced from the comparison between the baseline and the two-year follow-up data in terms of, for example, the incidence of the different disorders and the identification of possible short-term risk or protective factors.
The data from the study of family caregivers were processed.
2014 - Second (final) follow-up of the population
In this second follow-up phase, provision was made for a further multidisciplinary assessment. Scheduled at an interval of four years from the first, this was the third such assessment and it was performed using the same instruments used in the previous ones. A total of 1,o14 people took part in this phase, corresponding to 85.7 % of the members who could be recruited.
2015 – End of the research study
The whole of 2015 was devoted to the final data processing and the writing of the research report and of scientific papers based on the data generated by the study.
THE STUDY BEGAN IN NOVEMBER 2009
THE FIRST POPULATION ASSESSMENT PHASE WAS COMPLETED IN JANUARY 2011
THE SECOND ASSESSMENT BEGAN ON FEBRUARY 6, 2012 AND ENDED ON FEBRUARY 28, 2013.
THE THIRD ASSESSMENT WILL BEGIN ON FEBRUARY 19, 2014 AND WAS COMPLETED ON NOVEMBER 2014.