Brain Aging in Abbiategrasso

The Study "InveCe.Ab" (Cerebral Aging in Abbiategrasso), is a longitudinal population-based study on the diseases of brain aging that plans to evaluate and follow over time the physical and cognitive conditions of all residents of Abbiategrasso born between 1935 and 1939, about 1,700 people.

2010 - Population screening

Assessment of socioenvironmental, clinical, and neuropsychological variables in the study population. Screening began in mid-November 2009 and was completed in January 2011.

It provided for each participant two appointments at the Foundation or in case of need at home. Participated 1,321 people equal to 80.2% of recruitable people.

2011 - Train-mind

Randomized controlled trial to evaluate the effects of randomly assigned Cognitive Stimulation and Health Education Groups for approximately 180 individuals drawn from the evaluated population. I gruppi sono partiti a febbraio 2011 e terminati alla fine del 2011.

2012 - Phase 3: First Interim Population Reassessment

On February 6, 2012 the Follow-up Phase began with a new screening of cognitive functions of people who participated in the first phase and detection of clinical events occurred and analysis of incidence and risk factors and protectionil follow up si è concluso il 28 febbraio 2013. Hanno partecipato 1.113 persone pari al 85,5% della popolazione complessiva, 90 % delle persone reclutabili.

2013 - Phase 4: Evaluation of collected data and study of family care givers

A study was planned on the care and family burden on a selected group of family members of the participants in the research, through interviews conducted by members of the center's team. This collection of information was completed between the end of April and the beginning of May 2013.

Biological and genetic analysis: the blood samples collected will be typed for any additional genetic factors and a series of biological parameters can be compared with the data of the first screening and follow-up.

Data processing: The new large mass of data collected with the second screening will be processed again, but above all, the analysis of what can be derived from the comparison between the initial assessment and the two-year follow-up will be initiated: from the incidence of diseases to the isolation of possible risk factors or short-term protection.

Processing data from the care givers study.

2014 - Phase 5: Final Population Reassessment

Second phase of follow-up with a new screening evaluation (the third, therefore) on the progress of cognitive functions at a distance of 4 years always using the same instruments. 1010 participants were recruited, a % adherence of the people who participated in the first screening.

2015 - Phase 6: Research Conclusion

Throughout 2015, final data processing and writing of the research report and scholarly articles that can make use of the overall research data took place.

Materials:

Information flyer 1st screening


THE STUDY STARTED IN NOVEMBER 2009

THE FIRST PHASE OF POPULATION SCREENING ENDED AT THE END OF 2010 

THE SECOND SCREENING STARTED ON FEBRUARY 6, 2012 AND ENDED ON FEBRUARY 28, 2013.

THE THIRD SCREENING STARTED ON FEBRUARY 19, 2014 AND ENDED AT THE END OF NOVEMBER 2014.